Planetary Mixers Produce Nano-Particle Suspensions

Intertronics has developed a mixing process for engineering compounds using the Thinky ARV-310 and Thinky ARV-5000 industrial non-contact planetary mixers. In particular these machines are suitable for creating nano-particle suspensions of medical compounds more reliably and quicker than traditional methods, according to Intertronics. This can often overcome problems of dilution where materials have negligible water solubility and enable mixing, dispersal and degassing in amounts as small as 0.5ml, up to large, laboratory level quantities.

The new process involves use of a Thinky mixer with zirconia balls, which can pulverise poorly water-soluble compounds such as medical drug doses using the 2,000rpm planetary technology. In addition, use of the ARV vacuum mixer enables complete elimination of all air bubbles. Commonly, a pestle and mortar are used for oral dosage formulations. While this method is generally accepted and effective, this manual hand process is tedious and can lack repeatability or consistency.

The technique introduced by Intertrnoics is called NH-Step. The company said that the NH-Step makes the mixing process easy, fast, improves physiochemical properties and can be applied to many oral suspensions. For example, with an initial particle size of 18 micron, utilising the NH-Step process the particle distribution was reduced to two microns after only three minutes with the Thinky ARE-250.

The Thinky ARV-310 and Thinky ARV-5000 have the ability to process under vacuum, or under normal pressure, or even automatically switching into vacuum mode from non-vacuum state during the process. It is possible to set the desired vacuum level for different types of ingredients. These mixers are suitable for high-viscosity materials and materials for which a high degree of de-aeration is required. They can eliminate micron-sized bubbles, without the danger of foaming and messy spillage.

Comments

Post a Comment

Popular posts from this blog

What is Class I Division 2?

Image
A Class I Division 2 is a location: (1) In which volatile flammable gases, flammable liquid-produced vapors, or combustible liquid-produced vapors are handled, processed, or used, but in which the liquids, vapors, or gases will normally be confined within closed containers or closed systems from which they can escape only in case of accidental rupture or breakdown of such containers or systems or in case of abnormal operation of equipment, or (2) In which ignitable concentrations of flammable gases, flammable liquid-produced vapors, or combustible liquid-produced vapors are normally prevented by positive mechanical ventilation, and which might become hazardous through failure or abnormal operation of the ventilating equipment. Class I Division 2 Classification Class I Division 2 refers to the ANSI/ISA 12.12.01 standard. This standard was previously UL1604 until UL recommended the newer ANSI/ISA standard be used and that all hazardous location products be certified under this standa
Read more

FUSE SIZING CONSIDERATIONS FOR HIGHER EFFICIENCY MOTORS

Image
When selecting the proper fuse for short circuit protection in motor starting applications, it is important to not only ensure that the fuse will not nuisance open during motor start up times, but also that the fuse will coordinate as required with overload relays. When sizing fuses between 125% and 150% of the motor nameplate current, several advantages, including ease of coordination with an overload device, a smaller disconnect, and increased short circuit protection from a lower fuse rating, can be achieved. However, if sizing at this level prevents the motor from starting, it may then be necessary to increase the fuse ampere rating and it then becomes important to know the NEC sizing limitations. As of June 1, 2016, the US Department of Energy has mandated that newly manufactured electric motors will need to meet NEMA Premium® efficiency standards. As motor efficiencies increase, motor locked rotor currents can also be expected to increase. In addition to this, with across-the-lin
Read more

7/8 16UN Connectors that Provide 600 Volts and 15 Amps

TURCK announces new A-Size 3 and 4-pin 7/8 16UN powerfast™ connectors that provide up to 600 Volts and 15 Amps of power. These IP67 rated connectors provide a modular wiring system designed to handle high current applications for machine power distribution, while providing resistance to vibration commonly associated with conveyors, motors and material handling applications. The cordsets are available with a tray rated, exposed run PVC flexlife ® cable, with or without STOOW rating, and 14 AWG wires that allow you to replace hard wiring with a robust, quick disconnect system that saves the time and money spent installing a conduit system. The A-Size powerfast line offers male and female, straight connectors, standard and custom lengths, and pigtails or extensions. To make the system complete, fully encapsulated mating receptacles, with 1/2”-14 NPT mounting threads are available.
Read more